XenoFinder Co., Ltd

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产品分类: Our Services; In Vitro Metabolite Identification of Small Molecule Drugs; In Vivo Metabolism and Disposition of Small Molecule Drugs; Radiolabeled ADME Studies in Animals and Humans; ADME Studies of Antibody-Drug Conjugates (ADCs); Biotransformation of New Drug Modalities; Metabolizing Enzyme Phenotyping

产品中心: Metabolic soft spot analysis in liver microsomes, hepatocytes and other in vitro systems; GSH-trapping of reactive metabolites in liver microsomes; Comparative metabolism across species in liver microsomes, hepatocytes and other in vitro systems; Biotransformation of slowly metabolized drugs in 3D hepatocyte spheroid culture; ADME studies in mice, rats, dogs, monkeys, and other animal species; Metabolite profiling and identification in plasma, urine, feces, bile and tissue samples from pharmacokinetics, pharmacology, toxicology, and clinical studies; Comparative metabolite profiling in plasma of human and Tox species for MIST evaluation; Radiolabeled mass balance and ADME studies in mice, rats, dogs, monkeys, and other animal species; QWBA tissue distribution studies in mice and rats; Human mass balance study; Profiling and identification of payload-containing components released from an ADC in vitro; In vitro metabolite profiling and metabolizing enzyme phenotyping of payloads; Metabolite profiling and identification of payloads in rats, monkeys and other animal species; ADME study of radiolabeled ADCs and payloads in rats, monkeys and other animals; Studies of payload release and ADME of other antibody conjugates, including antibody-peptide conjugate (APC), antibody-oligonucleotide conjugate (AOC), and degrader-antibody conjugate (DAC); In vitro and in vivo metabolite profiling and identification of peptide-containing therapeutics, including peptide drug conjugate (PDC) and radionuclide drug conjugate (RDC); In vitro and in vivo metabolite profiling and identification of oligonucleotides; Metabolite profiling and identification of proteolysis-targeting chimeras (PROTACs) and small molecule drug conjugates (SMDCs); ADME studies of radiolabeled peptide, PDC, oligoneucides, PROTAC and SMDC therapeutics in rats, monkeys and other animal species; Identification of the role of AO in drug metabolism; CYP phenotyping in drug discovery; Phenotyping of other metabolizing enzymes; Enzyme kinetic studies of metabolite formation; Definitive CYP enzyme phenotyping; 在肝微粒体/胞浆/S9、肝细胞和其他体外系统中进行多种属的比较代谢分析; 在3D肝细胞球（合珀）培养中进行慢代谢药物的生物转化

新闻分类: Resources; Scientific Publication by Researchers at XenoFinder; Scientific Presentations; Service Brochures; Biotransformation References; News & Events

新闻资讯: Drug metabolism in discovery and development; Biotransformation of new drug modality and botanic drugs; Metabolizing enzyme phenotyping; In vivo metabolism and disposition; In vitro metabolite identification; Radiodetection methods and radiolabeled ADME study; LC-MS methods applied to metabolite identification; 2022 ISSX Poster: Sensitive and selective detection and characterization of drug metabolites in human plasma by LC-HRMS: development and application of matrix removal-based data processing strategy; 2023 ISSX Poster (2): identifying accurate metabolism sites of vepdegestrant（arv-471） using novel electron-activated dissociation high-resolution mass spectrometry; 2023 ISSX poster (1): an overview of CDE technical guideline for nonclinical study of ADCs: importance and strategy of studying release of payload-containing components from ADC and their further metabolism; 2024 ISSX Poster (2): Comprehensive metabolite profiling of SHR0302 in human urine and feces using LC-HRMS and an advanced data processing workflow: Comparison with radiochromatographic analysis; 2024 ISSX Poster (1): In vitro study of payload release from an ADC using LC-HRMS and untargeted data processing: Identification of a new payload release pathway of DS-0821a; Biotransformation of peptide-containing therapeutics; Biotransformation of oligonucleotides; Metabolite profiling and ADME studies of ADCs; Radiolabeled ADME study in animals and humans; Research capability and services of XenoFinder; Recommended research papers; Industrial position papers; Regulatory guidance; Dr. Mingshe Zhu delivered an oral presentation titled “ADME Characterization Strategies and Approaches of ADCs” at the 2025 DVDMDG Spring Symposium; A poster titled “A Universal LC-HRMS Method for Rapid and Comprehensive Metabolite Profiling and Identification of Oligonucleotide Therapeutics” was presented at the 2025 ASMS Annual Conference

图片分类: Platforms; Advanced LC-HRMS Data-Processing Tools; Metabolite Profiling Techniques of New Drug Modalities; Radiolabeled ADME Solution; Investigative Drug Metabolism; ADME Characterization of Botanic Drugs; Biotransformation Consulting; About Us; Who We Are; Our Mission; Business Conduct and Ethics; Why choose us

图片列表: Case study: Detection and characterization of ranitidine metabolites in human plasmausing LC-HRMS and background subtraction filter (BSF); Case Study (2): Identification of a new payload release pathway of DS-0821a using the untargeted LC-HRMS method; o Case Study (3): Detection and identification of in vitro metabolites of inclisiran using a novel and universal LC-HRMS method; o Case Study (4): A universal LC-HRMS method for metabolite Detection and identification of peptide-based drugs; Case Study (5): Profiling and characterization of botanic components in rat plasma using LC-HRMS and multiple data processing tools.

单页分类: Contact Us

单页列表: Metabolic soft spot analysis in liver microsomes, hepatocytes and other in vitro systems