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Biotransformation of new drug modality and botanic drugs

Biotransformation of New Drug Modality and Botanic Drug

- W. Wang, C. Chen, J. Luo, C. Tang, Y. Zheng, S. Yan, Y. Yuan, M. Zhu, X. Diao, T. Hang, H. Wang. Metabolism investigation of the peptide-drug conjugate LN005 in rats using UHPLCHRMS. Journal of pharmaceutical and biomedical analysis. 2024;238:115860.

- Y. Yuan, W. Wang, J. Luo, C. Tang, Y. Zheng, J. Yu, H. Xu, M. Zhu, T. Hang, H. Wang, X. Diao. Metabolite characterization of the peptide-drug conjugate LN005 in liver S9s by UHPLC-Orbitrap-HRMS. Xenobiotica; the fate of foreign compounds in biological systems. 2023:1-9.

- T. Cai, L. Shi, H. Guo, R. Li, W. Cao, L. Shen, M. Zhu, Y. Tao. Detection and Characterization of In Vitro Payload-Containing Catabolites of Noncleavable Antibody-Drug Conjugates by High-Resolution Mass Spectrometry and Multiple Data Mining Tools. Drug metabolism and disposition: the biological fate of chemicals. 2023;51(5):591-8.

- X. Jiang, S. Chen, M. Zhu, C. Wu. Global Xenobiotic Profiling of Rat Plasma Using Untargeted Metabolomics and Background Subtraction-Based Approaches: Method Evaluation and Comparison. Current drug metabolism. 2023;24(3):200-10.

- C. Zhou, Z. Fan, Z. Zhou, Y. Li, R. Cui, C. Liu, G. Zhou, X. Diao, H. Jiang, M. Zheng, S. Zhang, T. Xu. Discovery of the First-in-Class Agonist-Based SOS1 PROTACs Effective in Human Cancer Cells Harboring Various KRAS Mutations. Journal of medicinal chemistry. 2022;65(5):3923-42.

- J. Chen, X. Jiang, C. Zhu, L. Yang, M. Liu, M. Zhu, C. Wu. Exploration of Q-Marker of Rhubarb Based on Intelligent Data Processing Techniques and the AUC Pooled Method. Frontiers in pharmacology. 2022;13:865066.

- X. Bai, C. Zhu, J. Chen, X. Jiang, Y. Jin, R. Shen, M. Zhu, C. Wu. Recent Progress on Mass Spectrum Based Approaches for Absorption, Distribution, Metabolism, and Excretion Characterization of Traditional Chinese Medicine. Current drug metabolism. 2022;23(2):99-112.

- Y. Zeng, W. Shi, Q. Dong, W. Li, J. Zhang, X. Ren, C. Tang, B. Liu, Y. Song, Y. Wu, X. Diao, H. Zhou, H. Huang, F. Tang, W. Huang. A Traceless Site-Specific Conjugation on Native Antibodies Enables Efficient One-Step Payload Assembly. Angewandte Chemie (International ed in English). 2022;61(36):e202204132.

- M. Yao, T. Cai, E. Duchoslav, L. Ma, X. Guo, M. Zhu. Software-aided detection and structural characterization of cyclic peptide metabolites in biological matrix by high-resolution mass spectrometry. Journal of pharmaceutical analysis. 2020;10(3):240-6.

- X. Chen, Y. Wu, C. Chen, Y. Gu, C. Zhu, S. Wang, J. Chen, L. Zhang, L. Lv, G. Zhang, Y. Yuan, Y. Chai, M. Zhu, C. Wu. Identifying potential anti-COVID-19 pharmacological components of traditional Chinese medicine Lianhuaqingwen capsule based on human exposure and ACE2 biochromatography screening. Acta pharmaceutica Sinica B. 2021;11(1):222-36.

- M. Yao, B. Chen, W. Zhao, J. T. Mehl, L. Li, M. Zhu. LC-MS Differential Analysis for Fast and Sensitive Determination of Biotransformation of Therapeutic Proteins. Drug metabolism and disposition: the biological fate of chemicals. 2018;46(4):451-7.

- Y. Q. Xia, E. Ciccimaro, N. Zheng, M. Zhu. Differential mobility spectrometry combined with multiple ion monitoring for bioanalysis of disulfide-bonded peptides with inefficient collision-induced dissociation fragmentation. Bioanalysis. 2017;9(2):183-92.

- J. Jiang, X. Pang, L. Li, X. Dai, X. Diao, X. Chen, D. Zhong, Y. Wang, Y. Chen. Effect of N-methyl deuteration on metabolism and pharmacokinetics of enzalutamide. Drug design, development and therapy. 2016;10:2181-91.

- C. Wu, H. Zhang, C. Wang, H. Qin, M. Zhu, J. Zhang. An Integrated Approach for Studying Exposure, Metabolism, and Disposition of Multiple Component Herbal Medicines Using High-Resolution Mass Spectrometry and Multiple Data Processing Tools. Drug metabolism and disposition: the biological fate of chemicals. 2016;44(6):800-8.

- Q. Ruan, Q. C. Ji, M. E. Arnold, W. G. Humphreys, M. Zhu. Strategy and its implications of protein bioanalysis utilizing high-resolution mass spectrometric detection of intact protein. Analytical chemistry. 2011;83(23):8937-44