Metabolizing Enzyme Phenotyping

- Y. Zhou, H. Dong, J. Fan, M. Zhu, L. Liu, Y. Wang, P. Tang, X. Chen. Cytochrome P450 2B6 and UDP-Glucuronosyltransferase Enzyme-Mediated Clearance of Ciprofol (HSK3486) in Humans: The Role of Hepatic and Extrahepatic Metabolism. Drug metabolism and disposition: the biological fate of chemicals. 2024;52(2):106-17.

- Y. Zheng, H. Zhang, M. Liu, G. Li, S. Ma, Z. Zhang, H. Lin, Y. Zhan, Z. Chen, D. Zhong, L. Miao, X. Diao. Pharmacokinetics, Mass Balance, and Metabolism of the Novel Urate Transporter 1 Inhibitor [(14)C]HR011303 in Humans: Metabolism Is Mediated Predominantly by UDP-Glucuronosyltransferase. Drug metabolism and disposition: the biological fate of chemicals. 2022;50(6):798-808.

- X. Pang, C. Tang, R. Guo, X. Chen. Non-cytochrome P450 enzymes involved in the oxidative metabolism of xenobiotics: Focus on the regulation of gene expression and enzyme activity. Pharmacology & therapeutics. 2022;233:108020.

- L. L. Pan, Y. Yang, M. Hui, S. Wang, C. Y. Li, H. Zhang, Y. H. Ding, L. Fu, X. X. Diao, D. F. Zhong. Sulfation predominates the pharmacokinetics, metabolism, and excretion of forsythin in humans: major enzymes and transporters identified. Acta pharmacologica Sinica. 2021;42(2):311-22.

- X. Pang, C. Tang, F. Kong, M. Chen, X. Chen. CYP2C and CYP2B Mediated Metabolic Activation of Retrorsine in Cyp3a Knockout Mice. Current drug metabolism. 2020;21(13):1040-51.

- X. Y. Liu, Z. T. Guo, Z. D. Chen, Y. F. Zhang, J. L. Zhou, Y. Jiang, Q. Y. Zhao, X. X. Diao, D. F. Zhong. Alflutinib (AST2818), primarily metabolized by CYP3A4, is a potent CYP3A4 inducer. Acta pharmacologica Sinica. 2020;41(10):1366-76.

- T. Zhang, K. Zhang, L. Ma, Z. Li, J. Wang, Y. Zhang, C. Lu, M. Zhu, X. Zhuang. Metabolic Pathway of Icotinib In Vitro: The Differential Roles of CYP3A4, CYP3A5, and CYP1A2 on Potential Pharmacokinetic Drug-Drug Interaction. Journal of pharmaceutical sciences. 2018;107(4):979-83.

- Y. Zhu, F. Wang, Q. Li, M. Zhu, A. Du, W. Tang, W. Chen. Amlodipine metabolism in human liver microsomes and roles of CYP3A4/5 in the dihydropyridine dehydrogenation. Drug metabolism and disposition: the biological fate of chemicals. 2014;42(2):245-9.

- X. Diao, X. Pang, C. Xie, Z. Guo, D. Zhong, X. Chen. Bioactivation of 3-n-butylphthalide via sulfation of its major metabolite 3-hydroxy-NBP: mediated mainly by sulfotransferase 1A1. Drug metabolism and disposition: the biological fate of chemicals. 2014;42(4):774-81.

- R. Gao, L. Li, C. Xie, X. Diao, D. Zhong, X. Chen. Metabolism and pharmacokinetics of morinidazole in humans: identification of diastereoisomeric morpholine N+-glucuronides catalyzed by UDP glucuronosyltransferase 1A9. Drug metabolism and disposition: the biological fate of chemicals. 2012;40(3):556-67.

- B. Wen, L. Ma, A. D. Rodrigues, M. Zhu. Detection of novel reactive metabolites of trazodone: evidence for CYP2D6-mediated bioactivation of m-chlorophenylpiperazine. Drug metabolism and disposition: the biological fate of chemicals. 2008;36(5):841-50.

- M. Yao, M.  Zhu, S. Chang, D. Zhang and A Rodrigues. Chapter 15. Applications of recombinant and purified human drug-metabolizing enzymes: an industrial perspective, in Handbook of Drug Metabolism”, 2nd Edition; Editors, L. C. Wienkers and P. G. Pearson. Taylor & Francis, Inc. November 2008.

- D. Zhang, L. Wang, G. Chandrasena, L. Ma, M. Zhu, H. Zhang, C. D. Davis, W. G. Humphreys. Involvement of multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes in the in vitro metabolism of muraglitazar. Drug metabolism and disposition: the biological fate of chemicals. 2007;35(1):139-49.

- M. Zhu, W. Zhao, H. Jimenez, D. Zhang, S. Yeola, R. Dai, N. Vachharajani, J. Mitroka. Cytochrome P450 3A-mediated metabolism of buspirone in human liver microsomes. Drug metabolism and disposition: the biological fate of chemicals. 2005;33(4):500-7.

- N. Raghavan, D. Zhang, M. Zhu, J. Zeng, L. Christopher. Cyp2D6 catalyzes 5-hydroxylation of 1-(2-pyrimidinyl)-piperazine, an active metabolite of several psychoactive drugs, in human liver microsomes. Drug metabolism and disposition: the biological fate of chemicals. 2005;33(2):203-8.

- D. Zhang, W. Zhao, V. A. Roongta, J. G. Mitroka, L. J. Klunk, M. Zhu. Amide N-glucuronidation of MaxiPost catalyzed by UDP-glucuronosyltransferase 2B7 in humans. Drug metabolism and disposition: the biological fate of chemicals. 2004;32(5):545-51.