In Vitro Metabolite Identification of Small Molecule Drugs
Metabolic soft spot analysis in liver microsomes, hepatocytes and other in vitro systems
Metabolic stability analysis and metabolite profiling in liver microsomes, hepatocytes and other in vitro systems
GSH-trapping of reactive metabolites in liver microsomes
Comparative metabolism across species in liver microsomes, hepatocytes and other in vitro systems
Biotransformation of slowly metabolized drugs in 3D hepatocyte spheroid culture
In Vivo Metabolism and Disposition of Small Molecule Drugs
ADME studies in mice, rats, dogs, monkeys, and other animal species
Metabolite profiling and identification in plasma, urine, feces, bile and tissue samples from pharmacokinetics, pharmacology, toxicology, and clinical studies
Comparative metabolite profiling in plasma of human and Tox species for MIST evaluation
Radiolabeled ADME Studies in Animals and Humans
Radiolabeled mass balance and ADME studies in mice, rats, dogs, monkeys, and other animal species
QWBA tissue distribution studies in mice and rats
Human mass balance study
ADME Studies of Antibody-Drug Conjugates (ADCs)
Profiling and identification of payload-containing components released from an ADC in vitro
In vitro metabolite profiling and metabolizing enzyme phenotyping of payloads
Metabolite profiling and identification of payloads in rats, monkeys and other animal species
ADME study of radiolabeled ADCs and payloads in rats, monkeys and other animals
Studies of payload release and ADME of other antibody conjugates, including antibody-peptide conjugate (APC), antibody-oligonucleotide conjugate (AOC), and degrader-antibody conjugate (DAC)
Biotransformation of New Drug Modalities
In vitro and in vivo metabolite profiling and identification of peptide-containing therapeutics, including peptide drug conjugate (PDC) and radionuclide drug conjugate (RDC)
In vitro and in vivo metabolite profiling and identification of oligonucleotides
Metabolite profiling and identification of proteolysis-targeting chimeras (PROTACs) and small molecule drug conjugates (SMDCs)
ADME studies of radiolabeled peptide, PDC, oligoneucides, PROTAC and SMDC therapeutics in rats, monkeys and other animal species
Metabolizing Enzyme Phenotyping
Identification of the role of AO in drug metabolism