CN

Menu

Search for more information
Our Services
  • In Vitro Metabolite Identification of Small Molecule Drugs
    In Vitro Metabolite Identification of Small Molecule Drugs
    Metabolic soft spot analysis in liver microsomes, hepatocytes and other in vitro systems
    Metabolic stability analysis and metabolite profiling in liver microsomes, hepatocytes and other in vitro systems
    GSH-trapping of reactive metabolites in liver microsomes
    Comparative metabolism across species in liver microsomes, hepatocytes and other in vitro systems
    Biotransformation of slowly metabolized drugs in 3D hepatocyte spheroid culture
  • In Vivo Metabolism and Disposition of Small Molecule Drugs
    In Vivo Metabolism and Disposition of Small Molecule Drugs
    ADME studies in mice, rats, dogs, monkeys, and other animal species
    Metabolite profiling and identification in plasma, urine, feces, bile and tissue samples from pharmacokinetics, pharmacology, toxicology, and clinical studies
    Comparative metabolite profiling in plasma of human and Tox species for MIST evaluation
  • Radiolabeled ADME Studies in Animals and Humans
    Radiolabeled ADME Studies in Animals and Humans
    Radiolabeled mass balance and ADME studies in mice, rats, dogs, monkeys, and other animal species
    QWBA tissue distribution studies in mice and rats
    Human mass balance study
  • ADME Studies of Antibody-Drug Conjugates (ADCs)
    ADME Studies of Antibody-Drug Conjugates (ADCs)
    Profiling and identification of payload-containing components released from an ADC in vitro
    In vitro metabolite profiling and metabolizing enzyme phenotyping of payloads
    Metabolite profiling and identification of payloads in rats, monkeys and other animal species
    ADME study of radiolabeled ADCs and payloads in rats, monkeys and other animals
    Studies of payload release and ADME of other antibody conjugates, including antibody-peptide conjugate (APC), antibody-oligonucleotide conjugate (AOC), and degrader-antibody conjugate (DAC)
  • Biotransformation of New Drug Modalities
    Biotransformation of New Drug Modalities
    In vitro and in vivo metabolite profiling and identification of peptide-containing therapeutics, including peptide drug conjugate (PDC) and radionuclide drug conjugate (RDC)
    In vitro and in vivo metabolite profiling and identification of oligonucleotides
    Metabolite profiling and identification of proteolysis-targeting chimeras (PROTACs) and small molecule drug conjugates (SMDCs)
    ADME studies of radiolabeled peptide, PDC, oligoneucides, PROTAC and SMDC therapeutics in rats, monkeys and other animal species
  • Metabolizing Enzyme Phenotyping
    Metabolizing Enzyme Phenotyping
    Identification of the role of AO in drug metabolism
    CYP phenotyping in drug discovery
    Phenotyping of other metabolizing enzymes
    Enzyme kinetic studies of metabolite formation
    Definitive CYP enzyme phenotyping