At XenoFinder, our biotransformation consulting services are designed to help pharmaceutical and biotech clients navigate the complex landscape of drug metabolism and ADME science. With deep scientific expertise and extensive hands-on experience, we provide strategic guidance that supports smarter drug design, development, and regulatory success.

What We Offer

Strategic Study Design

· Tailored recommendations for in vitro and in vivo biotransformation studies

· Guidance on appropriate species selection, time points, and matrices

· Integration of biotransformation considerations into your overall DMPK strategy

Metabolite Identification & Characterization

· Interpretation of LC-HRMS and radiodetection data

· Structural elucidation of metabolites

· Assessment of major and minor pathways, metabolic soft spots, and active metabolites

Regulatory Support

· Expert input on MIST (Metabolites in Safety Testing) compliance

· Support for IND, NDA, and global regulatory submissions

· Preparation or review of regulatory documents, summaries, and responses

Mechanistic Insight & Troubleshooting

· Mechanistic evaluation of unusual or unexpected metabolic pathways

· Root-cause analysis of metabolic liabilities or PK and PK/PD issues

New Modalities & Complex Compounds

· Biotransformation strategy for ADCs, peptides, oligonucleotides, and botanical drugs

· Specialized knowledge in handling hybrid molecules and novel conjugates

Collaborative Support

· Act as an external scientific advisor to your discovery or development team

·Participate in project team meetings, study reviews, or regulatory discussions