In vivo metabolism and disposition

- A. Zhou, Z. Wang, X. Diao, D. Zhong. Characterization of in-vivo human metabolites of the oral nucleoside anti-COVID-19 drug VV116 using UHPLC-Orbitrap-MS. Journal of pharmaceutical and biomedical analysis. 2023;228:115340.

- Z. Guo, M. Liu, J. Meng, Y. Xue, Q. Huang, Y. Zheng, Y. Wu, Z. Chen, J. Yu, D. Zhong, G. Li, X. Chen, X. Diao. Mechanistic Study on the Species Differences in Excretion Pathway of HR011303 in Humans and Rats. Drug metabolism and disposition: the biological fate of chemicals. 2022;50(6):809-18.

- C. Tang, X. Pang, Z. Guo, R. Guo, L. Liu, X. Chen. Dual Action of Acidic Microenvironment on the Enrichment of the Active Metabolite of Disulfiram in Tumor Tissues. Drug metabolism and disposition: the biological fate of chemicals. 2021;49(6):434-41.

- X. Pang, C. Tang, P. Cao, L. Zhou, X. Chen. Metabolic Activation of Retrorsine may Disrupt Bile Acid Homeostasis in Mice through the Nrf2 Pathway. Current drug metabolism. 2021;22(11):870-81.

- T. Hu, X. Ge, J. Wang, N. Zhang, X. Diao, L. Hu, X. Wang. Metabolite identification of iridin in rats by using UHPLC-MS/MS and pharmacokinetic study of its metabolite irigenin. Journal of chromatography B, Analytical technologies in the biomedical and life sciences. 2021;1181:122914.

- C. Zhu, M. Wan, H. Cheng, H. Wang, M. Zhu, C. Wu. Rapid detection and structural characterization of verapamil metabolites in rats by UPLC-MSE and UNIFI platform. Biomedical chromatography : BMC. 2020;34(1):e4702.

- C. Tang, L. Li, X. Ma, J. Wang, B. Chen, X. Dai, Y. Zhang, X. Chen. Qualitative and quantitative determination of anaprazole and its major metabolites in human plasma. Journal of pharmaceutical and biomedical analysis. 2020;183:113146.

- L. Pan, S. Guo, X. Chen, X. Jiang, J. Shen, X. Diao, Z. Wang, D. Zhong. Characterization of TPN171 metabolism in humans via ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2019;172:302-10.

- J. Pu, F. Wang, W. Tang, M. Zhu. Biotransformation of Ilaprazole in Human Liver Microsomes and Human: Role of CYP3A4 in Ilaprazole Clearance and Drug-Drug Interaction. Drug metabolism and disposition: the biological fate of chemicals. 2018;46(10):1453-61.

- A. Wohlfarth, M. Roman, M. Andersson, F. C. Kugelberg, X. Diao, J. Carlier, C. Eriksson, X. Wu, P. Konradsson, M. Josefsson, M. A. Huestis, R. Kronstrand. 25C-NBOMe and 25I-NBOMe metabolite studies in human hepatocytes, in vivo mouse and human urine with high-resolution mass spectrometry. Drug testing and analysis. 2017;9(5):680-98.

- X. Diao, J. Carlier, M. Zhu, S. Pang, R. Kronstrand, K. B. Scheidweiler, M. A. Huestis. In vitro and in vivo human metabolism of a new synthetic cannabinoid NM-2201 (CBL-2201). Forensic toxicology. 2017;35(1):20-32.

- Y. Zhu, L. Li, G. Zhang, H. Wan, C. Yang, X. Diao, X. Chen, L. Zhang, D. Zhong. Metabolic characterization of pyrotinib in humans by ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry. Journal of chromatography B, Analytical technologies in the biomedical and life sciences. 2016;1033-1034:117-27.

- W. Xiao, G. Shen, X. Zhuang, X. Ran, M. Zhu, H. Li. Characterization of human metabolism and disposition of levo-tetrahydropalmatine: Qualitative and quantitative determination of oxidative and conjugated metabolites. Journal of pharmaceutical and biomedical analysis. 2016;128:371-81.

- X. Diao, K. Zhong, X. L. Li, D. F. Zhong, X. Y. Chen. Isomer-selective distribution of 3-n-butylphthalide (NBP) hydroxylated metabolites, 3-hydroxy-NBP and 10-hydroxy-NBP, across the rat blood-brain barrier. Acta pharmacologica Sinica. 2015;36(12):1520-7.